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The principal cytochrome P450 isoenzyme associated appears to generally be CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Roughly 85% of an oral dose seems from the urine within 24 hrs of administration, most as the glucuronide conjugate, with small quantities of other conjugates and unchanged drug.Make clear to patients and caregivers that nalo